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The effects of type 1 diabetes on cerebral white matter

Cited 52 time in Web of Science Cited 58 time in Scopus
Authors
Weinger, K.; Jacobson, A. M.; Musen, G.; Lyoo, I. K.; Ryan, C. M.; Jimerson, D. C.; Renshaw, P. F.
Issue Date
2007-12-25
Publisher
Springer Verlag
Citation
Diabetologia. 2008 ;51(3):417-25.
Keywords
AdultBlood PressureBrain/*pathologyDiabetes Mellitus, Type 1/blood/*pathology/physiopathologyFemaleFunctional LateralityHumansLipids/bloodMagnetic Resonance ImagingMaleReference Values
Abstract
AIM/HYPOTHESIS: Studies investigating the structure, neurophysiology and functional outcomes of white matter among type 1 diabetes patients have given conflicting results. Our aim was to investigate the relationship between type 1 diabetes and white matter hyperintensities. METHOD: We assessed white matter integrity (using magnetic resonance imaging), depressive symptoms and neuropsychological function in 114 type 1 diabetes patients and 58 age-matched non-diabetic controls. RESULTS: Only Fazekas grade 1 and 2 white matter hyperintensities were found among 114 long-duration, relatively young diabetes patients; the severity of lesions did not differ substantially from 58 healthy controls. White matter hyperintensities were not associated with depressive history or with clinical characteristics of diabetes, including retinopathy, severe hypoglycaemia or glycaemia control. CONCLUSIONS/INTERPRETATION: Our data do not support an association between diabetes characteristics and white matter hyperintensities among relatively young type 1 diabetes participants.
ISSN
0012-186X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18157661

http://hdl.handle.net/10371/63562
DOI
https://doi.org/10.1007/s00125-007-0904-9
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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