SHERP

Experimental Study on the Effects of Acute Carbon Monoxide Intoxication during Pregnancy on Fetal Growth in Rat
임신중 급성일산화탄소중독이 백서태자의 성장에 미치는 영향에 관한 실험적 연구

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Authors
Cho, Soo-Hun; Lee, Soo Dong; Yun, Dork Ro
Issue Date
1988-03
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1988;29(1):55-63
Keywords
Carbon monoxide poisoningHyperbaric oxygenationFetal growthMalformationPregnancy wastage
Abstract
This study was carried out to observe the effect of acute carbon monoxide (CO)
poisoning on the gestational process and outcome, and to develop the proper method to
evaluate it Primiparous Sprague-Dawley rats were exposed for 1 hour to a CO of 1800 ppm
or 2 hours to a CO of 1400 ppm resulting in blood carboxyhemoglobin levels of 68-72% on
day 11 of gestation when active organogenesis is beginning. Half the rats exposed to a CO of
1400 ppm for 2 hours were treated with hyperbaric oxygen (HBO) 15 minutes after CO
exposure.
Only the group exposed to a CO of 1400 ppm for 2 hours sustained significant damage to
the pregnancy. Though no significant pregnancy interruption resulted in the group exposed to
CO at a concentration of 1800 ppm for 1 hour, the fetal growth were significantly retarded.
The fetuses of rats treated with HBO after exposure to CO did not show growth retardation
other than a decrease in the ratio of biparietal diameter to crown-rump length. Carbon
monoxide was not found to be teratogenic in any experimental groups.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6360
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 29 No.1 (1988)
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