SHERP

Morphological Development of the Human Hypophysis
뇌하수체의 형태학적 발달

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Authors
Chi, Je G.; Lee, Yong Seok
Issue Date
1988-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1988;29(2):119-130
Keywords
AdenohypophysisNeurohypophysisDevelopmentEmbryo
Abstract
The morphological development of the human hypophysis was studied using
142 developing human hypophyses from 19 embryos and 123 fetuses. The adenohypophysis
first developed at 4 weeks of gestational age as an upward growing fold of the primitive oral
ectoderm Rathke's pouch. At 7 weeks, the configuration of pars distalis and pars intermedia
was formed. The Rathke's pouch lost its connection with the oral cavity completely at 8
weeks. Pars tuberalis became evident at 9 weeks. Histologically, capillary formation was found
at the end of 7 weeks in adenohypophysis and basophilic lamellated bodies were first identified
at 8 weeks. Cells with eosinophilic cytoplasm appeared at 9 weeks and those with
basophilic cytoplasm appeared between 10-12 weeks.
The neurohypophysis developed as a downward evagination of the diencephalic floor at 6
weeks. After 9 weeks, capillary formation occurred in the stroma, and primitive neuroepithelial
cells became differentiated. Ependymal tubules were also observed at this time. Between
25-29 weeks, suspicious pigment was seen in the cytoplasm of pituicytes and glial cell modification
into pituicytes seemed completed. No Herring body-like structures could be identified
throughout the fetal period.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6372
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 29 No.2 (1988)
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