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Effects of Adrenaline, Acetylcholine, Ca++ and K+ on the Conduction through the SA Node in the Rabbit
동방결절내에서의 흥분전도에 미치는 Adrenaline, Acetylcholine, Ca++ 및 K+의 영향

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Authors
Ahn, Cheol-Soo; Earm, Yung-E; Sung, Ho-Kyung
Issue Date
1988-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med, Vol.29 No.3, pp. 213-225
Keywords
SA nodeConduction timePacemaker shift
Abstract
Although many studies have been performed on the electrical properties of the
SA node, there are few studies on the conduction time through the SA node. The reason for
that lies mainly on the intrinsic characteristics of the SA node and problems in the applied
methods.
In order to investigate the effects of neurotransmitters and ions on the intranodal conduction,
the conduction time in various regions was studied in the SA node of the rabbit. A
small strip of 1 mm X 10 mm in parallel with crista terminalis was made, and two microelectrodes
were inserted in different locations. After having recorded the conduction time under
normal Tyrode solution, neurotransmitters (adrenaline, acetylcholine) or ions (Ca +- ". K+)
were applied, and their effects on the conduction time were observed.
The results obtained were as follows: in the presence of adrenaline, the conduction time
through the SA node was shortened and the pacemaker site was shifted downward. In the
presence of acetylcholine or 1 mM Ca + +, the conduction time was prolonged and the
pacemaker site was shifted downward. At under 8 mM Ca + +, the conduction time was
shortened and the pacemaker site was not shifted. The conduction time and the pacemaker
site were not affected under 1.5 mM K+ .
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6381
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 29 No.3 (1988)
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