SHERP

Clinical Study of Prophylactic Antibiotics to Determine the Optimum Duration of Administration
예방적 항생제의 적정 투여기간 결정을 위한 임상적 연구

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Authors
Kim, Jin-Pok; Kim, Sun-Whe
Issue Date
1985-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1985;26(2):221-227
Keywords
Antibiotic prophylaxisDecisive periodClean contaminated surgery
Abstract
To confirm the benefits of short term perioperative chemoprophylaxis a
prospective randomized comparative study was performed. The patients admitted for elective
gastroduodenal or biliary tract surgery had been enrolled. The patients were given two different
antibiotic regimens; cefazolin (I) or combination of penicillin and gentamicin (II), for three
different periods starting preoperatively; 1 day (group A), 3 days (group B) and 5 to 7 days
(group C). The each group of patients was similar in terms of age, sex, weight, duration of
operation, preoperative hospital days and distribution of disease and operation. The rate of
infection was 5.1% (5/99) in group A, 7.7% (8/104) in group Band 6.9% (7/101) in group C.
No significant difference was found between cefazolin alone (5.8%) and penicillin plus gentamicin
(7.3%) in the rate of infection. This result suggests that there is no benefit from
continuing antibiotic administration beyond the day of operation in preventing infectious complication
after clean contaminated operation.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6397
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 26 No.2 (1985)
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