SHERP

An Experimental Study on the Effect of Differential Ventriculomegaly on the Somatosensory Evoked Potential
차등적 뇌실 확장이 체성감각 유발전위에 미치는 영향에 관한 실험적 연구

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Authors
Cho, Byung-Kyu; Wang, Kyu Chang; Lee, Yong Jin; Kim, Hyun Jip; Choi, Kil Soo
Issue Date
1988-09
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1988;29(3):283-291
Keywords
HydrocephalusDifferential ventriculomegalySomatosensory evoked potentialIncreased intracranial pressureCentral conduction timeVulnerability of cerebral cortex
Abstract
Differential ventriculomegaly is encountered after head injury, craniectomy or
in some congenital hydrocephalic patients. The evoked potential studies have been widely
used for the functional evaluation of the neural tissue.
To evaluate the effect of ventriculomegaly on the somatosensory evoked potentials (SEP's)
and the effect of increased intracranial pressure (lCP) on SEP in ventriculomegaly, the
authors had recorded SEP in a differential ventriculomegaly model.
To make a differential ventriculomegaly model, twenty-eight cats had kaolin-injections
with cisternal puncture and hemicraniectomy. With the SEP studies of the cats in pre-hydrocephalic
phase, in post-hydrocephalic phase 4-8 weeks after kaolin-injection, and in increased
ICP phase, the effects of differential ventriculomegaly on the electrophysiologic
function of the brain were evaluated. The size of the ventricles were evaluated with brain CT
scan in 7 cats and with autopsy specimen in all 28 cats.
Intracranial kaolin-injection and hemicraniectomy produced asymmetrical ventriculomegaly
with the larger one on the hemicraniectomy side in 68%.
In pre-hydrocephalic and post-hydrocephalic phase studies with left-sided hemicraniectomy,
there were no significant side differences in the latencies. With the increased ICP,
there was a significant increase in the PI-Nl interpeak latency on the left side (p<O.Ol).
Comparing pre- and post-hydrocephalic phases, the latencies of wave II increased significantly
in both sides (p<O.Ol), but there was no significant difference between the increases
of both sides. There was no significant influence of the differential ventriculomegaly on the
central conduction time (II-PI) of the SEP's with or without increased ICP. The differential
ventriculomegaly with increased ICP did prolong the early cortical transmission (PI-Nl) of
the SEP's on the left side (p<O.Ol), which suggested greater vulnerability of cerebral cortex
compared with that of the right side.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6399
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 29 No.3 (1988)
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