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Parental Chromosomal Abnormalities in 50 Couples with Recurrent Spontaneous Abortions
반복 유산력이 있는 50쌍의 부부에 있어서 양친의 염색체 이상에 관한 연구

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Authors
Moon, Shin Yong; Shin, Hee Chul; Chang, Yoon Seok
Issue Date
1987-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(2):149-153
Keywords
Chromosomal abnormalitiesParentalRecurrent abortion
Abstract
Although the etiology of repetitive fetal wastage is unknown in many instances,
parental chromosomal rearrangements represent a well-established cause of repetitive spontaneous
abortions. And the frequency of parental translocations with recurrent spontaneous
abortions varies widely in reported series (4.7%-19.3%).
From January, 1980 to December, 1985, fifty couples with histories of two or more recurrent
abortions were evaluated cytogenetically with a GTG(G-band with Trypsin using Giemsa) technique.
The results were as follows:
1. In five (10%) of the couples with balanced translocations, four balanced carrier partners
(8%) were identified in husbands and one another (2%) in wives.
2. Pericentric inversion of the ninth chromosome were identified in two male partners (4%).
A high incidence (14%) of cytogenetic abnormalities were found in couples with recurrent
abortions. Chromosome analysis is advocated as a primary tool in the evaluation of couples
with repetitive fetal wastage.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6419
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.2 (1987)
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