A Case of Common Variable Immunodeficiency

Abstract

Common variable immunodeficiency is a heterogeneous group of disorders characterized by hypogammaglobulinemia, impaired antibody response and recurrent bacterial infections. Although it is represented by an acquired defect of humoral immunity, cellular defect is occasionally found. Though variable, it usually manifests in the second or third decade of life. This report deals with a case of common variable immunodeficiency in a 6-year-old boy who presented with recurrent infections since 3 7/12 years of age, associated with aortic aneurysm and involvement of the liver, testis and polyserosa, which were believed to be autoimmune in nature.