SHERP

Immunologic Classification of Acute Lymphoblastic Leukemia in Korean
급성 림프구성 백혈병의 면역학적 분류

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Cho, Han Ik; Park, Myoung Hee; Kim, Sang In; Kim, Noe Kyung; Kim, Byung Kook
Issue Date
1987-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(2):109-114
Keywords
Acute lymphoblastic leukemiaImmunologic classification
Abstract
Recent advance in immunology has led to important insight into lymphocyte
differentiation and the cellular origin of acute lymphoblastic leukemia(ALl). Leukemic cells
from 68 children and 60 adults with ALL were analyzed utilizing highly specific monoclonal
antibodies, terminal deoxynucleotidyl transferase and more traditional lymphocyte markers
such as sheep erythrocyte receptor and surface membrane immunoglobulin. Monoclonal antibodies
used were J5 detecting common ALL antigen (CALLA), OKT10, OKM1 and OKla 1
detecting HLA-DR. Four major subgroups of ALL were identified: in childhood ALL, common
ALL (58.8%), null ALL (20.6%), T-ALL (19.1%) and B-ALL (1.5%) and in adult ALL, common
ALL (60.0%), null ALL (25.0%), T-ALL (13.3%) and B-ALL 0.7%). The frequencies of expression
of the markers within each of the four major subgroups were also evaluated. In
T-ALL, 18% of childhood and 25% of adult cases expressed CALLA.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6428
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.2 (1987)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse