Giant Cell Transformation of the Liver in Chronic Hepatitis with Confluent Lobular Collapse (Report of A Case)
융합성 소엽 압괴(교괴사)를 동반한 만성 활동성 간염에 있어서의 간거대세포 전환증

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Kim, Yong Il; Shin, Sung Sik; Kim, Chung Yong
Issue Date
Seoul National University College of Medicine
Seoul J Med 1987;28(3):269-274
Giant cell transformationChronic active hepatitisConfluent lobular collapseLiverAdulthood
We present a case of diffuse giant cell transformation of the liver in an adult
male patient with known chronic active hepatitis who recently developed confluent lobular collapse.
The patient was a 41 year-old man with known chronic liver disease under close follow-
up for 5 years, who was recently given 400 packs of unknown herb medicine for newly
developed duodenal ulcer. Subsequently slow progressive abnormalities of liver function test
developed. Hepatic needle biopsy showed considerably compromised lobular architectures by
the features of chronic active hepatitis with superimposed multifocal lobular collapse and diffuse
replacement of hepatocytes by multinucleated giant cells. Many giant cells showed intracytoplasmic
accumulation of protein -bound copper pigments and canalicular cholestasis. A
cytoplasmic mozaic pattern of stainability was partly related to the amount of glycogen in the
liver. Chronic active hepatitis with multifocal lobular collapse seems to be another causative
form of giant cell transformation of hepatocytes in adulthood, and this phenomenon is
assumed to reflect reparative process of immature hepatocytes following lobular collape.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.3 (1987)
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