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Decreased activity of brush border membrane-bound digestive enzymes in small intestines from pigs experimentally infected with porcine epidemic diarrhea virus

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Authors
Jung, K.; Ahn, K.; Chae, Chan Hee
Issue Date
2006-06-08
Publisher
Elsevier
Citation
Research in Veterinary Science 81, 310-315
Keywords
Alkaline phosphataseDisaccharidaseLeucine aminopeptidase NPigPorcine epidemic diarrhea virus
Abstract
Brush border membrane-bound digestive enzymes such as disaccharidases (lactase, sucrase, and maltase), leucine aminopeptidase N, and alkaline phosphatase were measured in jejunum from pigs experimentally infected with porcine epidemic diarrhea virus (PEDV). Three piglets from the infected and control groups were euthanized by electrocution and subjected to necropsy at 24, 36, 48, 60, and 72 hours post-inoculation (hpi). The infection of PEDV to jejunum resulted in significant decreases in brush border membrane-bound digestive enzymes such as disaccharidases (lactase, sucrase, and maltase), leucine aminopeptidase N, and alkaline phosphatase. PEDV replication results in massive destruction of villous enterocytes leading to a marked reduction of intestinal epithelial surface and brush border membrane-bound digestive enzyme activity. Reduced enzymatic activity and villous atrophy in the small intestine is thought to result in a maldigestive and malabsorptive diarrhea.
ISSN
0034-5288
Language
English
URI
http://hdl.handle.net/10371/6471
DOI
https://doi.org/10.1016/j.rvsc.2006.03.005
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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