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Effect of granulocyte macrophage-colony stimulating factor (GM-CSF) on 5-FU-induced ulcerative mucositis in hamster buccal pouches

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Authors
Cho, Sun-A; Park, Jong-Hwan; Seok, Seung-Hyeok; Juhn, Jae-Hyeon; Kim, Seong-Jin; Ji, Hyi-Jeong; Choo, Youn-Sung; Park, Jae Hak
Issue Date
2006-01-18
Publisher
Elsevier
Citation
Experimental and Toxicologic Pathology 2006;57:321–328
Keywords
MucositisGM-CSF5-FUHamster buccal pouchImmunohistochemistry
Abstract
The present study was performed to investigate the protective effects of granulocyte macrophage-colony stimulating factor (GM-CSF) against ulcerative mucositis in hamster buccal pouch. GM-CSF was topically administered to the buccal pouches of hamsters with two different doses of 5 and 20 μg/ml. The treatment of GM-CSF led to rapid healing effects in gross and histopathological findings. It decreased expression of pro-inflammatory cytokine mRNA levels in the mucosal tissue of buccal pouches. Also GM-CSF-treated animals showed high numbers of Ki-67 positive cells in basal cell layer. These results suggest that GM-CSF provided excellent healing effects to ulcerative mucositis in the buccal pouch of hamster.
ISSN
0940-2993
http://dx.doi.org/10.1016/j.etp.2005.09.006
Language
English
URI
http://hdl.handle.net/10371/6472
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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