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Gene Expression Profile by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Liver of Wild-Type (AhR+/+) and Aryl Hydrocarbon Receptor-Deficient (AhR-/-) Mice

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dc.contributor.authorYoon, Chang Yong-
dc.contributor.authorPark, Misun-
dc.contributor.authorKim, Bang Hyun-
dc.contributor.authorPark, Ji Yeon-
dc.contributor.authorPark, Mun Suk-
dc.contributor.authorJeong, Youn Kyoung-
dc.contributor.authorKwon, Hyugsung-
dc.contributor.authorJung, Hai Kwan-
dc.contributor.authorKang, HoIl-
dc.contributor.authorLee, Yong Soon-
dc.contributor.authorLee, Beom Jun-
dc.date.accessioned2009-08-07T03:30:08Z-
dc.date.available2009-08-07T03:30:08Z-
dc.date.issued2006-
dc.identifier.citationJ. Vet. Med. Sci. 68: 663-668en
dc.identifier.issn0916-7250 (print)-
dc.identifier.issn1347-7439 (online)-
dc.identifier.urihttp://hdl.handle.net/10371/6492-
dc.description.abstract,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic environmental pollutants that cause various biological effects on mammals. The purpose of our study was to identify the genes involved in hepatotoxicity and hepatocarcinogenesis caused by TCDD. C57BL/6 (AhR+/+, wild type) and B6.129-AhR/J (AhR-/-, knock out) mice were injected i.p. with a single treatment of TCDD at the dose of 100 microg/kg body weight. Relative liver weight was significantly increased at 72 hr after TCDD treatment without an apparent histopathological change in AhR+/+ mice (p3-fold) was changed in AhR+/+ mice; 28 genes were induced, while 23 genes were repressed. Most of the genes were associated with chemotaxis, inflammation, carcinogenesis, acute-phase response, immune responses, cell metabolism, cell proliferation, signal transduction, and tumor suppression. This study suggests that the microarray analysis of genes in the liver of AhR+/+ and AhR-/- mice may help to clarify the mechanism of AhR-mediated hepatotoxicity and hepatocarcinogenesis by TCDD.en
dc.description.sponsorshipThis work was financially supported by the Korea Food and Drug Administration Grant KFDA-04131-EDS-299en
dc.language.isoenen
dc.publisherJapanese Society of Veterinary Scienceen
dc.subjectgene expressionen
dc.subjectliveren
dc.subjectmicroarrayen
dc.subjectTCDDen
dc.titleGene Expression Profile by 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Liver of Wild-Type (AhR+/+) and Aryl Hydrocarbon Receptor-Deficient (AhR-/-) Miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor윤창용-
dc.contributor.AlternativeAuthor박미선-
dc.contributor.AlternativeAuthor김방현-
dc.contributor.AlternativeAuthor박지연-
dc.contributor.AlternativeAuthor박문숙-
dc.contributor.AlternativeAuthor정윤경-
dc.contributor.AlternativeAuthor권혁성-
dc.contributor.AlternativeAuthor정해관-
dc.contributor.AlternativeAuthor강호일-
dc.contributor.AlternativeAuthor이영순-
dc.contributor.AlternativeAuthor이범준-
dc.identifier.doi10.1292/jvms.68.663-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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