SHERP

Effect of Exercise on Hepatic Gene Expression in an Obese Mouse Model Using cDNA Microarrays

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Lee, Kyoung-Young; Kim, Su-Jong; Cha, Youn-Soo; So, Ju-Ryun; Park, Joon-Suk; Kang, Kyung-Sun; Chon, Tae-Won
Issue Date
2006
Publisher
The Obesity Society
Citation
Obesity. 2006;14:1294-1302
Keywords
cDNA microarrayC57BL/6J mouseexercise traininghigh-fat dietmetabolism
Abstract
To understand the molecular mechanisms involved in the effect of exercise training, we examined hepatic transcriptional profiles using cDNA microarrays in exercise-trained and untrained mice with diet-induced obesity. C57BL/6J male mice (n = 10/group) were fed with a normal diet, high-fat diet (HFD), or HFD with exercise training for 12 weeks. The expression level of 10,000 transcripts in liver tissues from each group was assessed using cDNA microarray analysis. Exercise training improved lipid profiles and hepatic steatosis and decreased body fat mass induced by the HFD. Seventy-three genes were differentially expressed in the HFD- and/or HFD with exercise training-treated groups, compared with the normal diet- and HFD-fed groups, respectively. Interestingly, the expression profiles involved in metabolism, such as elongation of very long chain fatty acids-like 2, lipin, and malic enzyme, were changed by exercise training. In addition, expression of genes altered by exercise training related to defense and stress response, including metallothionein 1 and 2 and heat shock protein, showed interesting findings. Our study showed beneficial effects of exercise training in preventing the development of obesity and metabolic disorders in mice with diet-induced obesity.
ISSN
1930-7381 (print)
1930-739X (online)
Language
English
URI
http://hdl.handle.net/10371/6496
DOI
https://doi.org/10.1038/oby.2006.147
Files in This Item:
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse