Expression of Mx protein and interferon-alpha in pigs experimentally infected with swine influenza virus

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Jung, K.; Chae, Chan Hee
Issue Date
American College of Veterinary Pathologists
Vet Pathol 43:161-167, 2006
H1N2 subtypeimmunohistochemistryinterferon-Mx proteinpigsswine influenza virus
Expression of Mx protein and interferon-a (IFN-a) was examined by immunohistochemistry
in pigs experimentally infected with swine influenza virus. In infected pigs euthanatized at 1 day
postinoculation (dpi), the lumen of bronchioles were filled with large numbers of mononuclear cells,
small numbers of neutrophils, sloughing epithelial cells, and proteinaceous fluid. Lesions at 3 and 5 dpi
were similar but less severe. Alveolar spaces were filled with neutrophils. By 7 and 10 dpi, microscopic
lesions were resolved. The immunohistochemical signals for Mx protein and IFN-a antigen were
confined to cells in areas that had hybridization signal for swine influenza virus. In situ hybridization
and immunohistochemistry of serial sections of lung indicated that areas containing numerous swine
influenza virus RNA-positive cells also have numerous Mx and IFN-a antigen-positive cells. Mean
immunohistochemical scores for Mx protein-positive cells were correlated with mean immunohistochemical
scores for IFN-a antigen-positive cells (rs 5 0.8799, P , 0.05). These results indicated that Mx
protein and IFN-a antigen were expressed in the lung from pigs experimentally infected with swine
influenza virus, but their biological functions remain to be examined.
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