Publications
Detailed Information
Mannosylated chitosan nanoparticle–based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae Hee | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Kim, Hyun Woo | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Cho, Chong Su | - |
dc.date.accessioned | 2009-08-07T06:59:47Z | - |
dc.date.available | 2009-08-07T06:59:47Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Mol Cancer Ther 2006;5:1723-1732 | en |
dc.identifier.issn | 1535-7163 | - |
dc.identifier.uri | https://hdl.handle.net/10371/6524 | - |
dc.description.abstract | Cancer immunotherapy relies on the ability of the immune system to destroy tumor cells selectively and to elicit a long-lasting memory of such activity. Interleukin-12 (IL-12) is an immunomodulatory cytokine produced primarily by antigen-presenting cells, which play an important role in promoting Th1-type immune response and cell-mediated immunity. To augment the antitumor immune action by in vivo IL-12 gene delivery, mannosylated chitosan (MC) was prepared to induce mannose receptor–mediated endocytosis of IL-12 gene directly into dendritic cells which reside within the tumor. Upon characterization, MC was proven to be suitable for IL-12 gene delivery due to good physicochemical properties and low cytotoxicity. In addition, MC exhibited much enhanced IL-12 gene transfer efficiency to dendritic cells rather than chitosan itself in terms of the induction of murine IL-12 p70 and murine IFN-γ. In animal studies, intratumoral injection of MC/plasmid encoding murine IL-12 complex into BALB/c mice bearing CT-26 carcinoma cells clearly suppressed tumor growth and angiogenesis, and significantly induced cell cycle arrest and apoptosis. Therefore, this study provides a new MC-mediated cytokine gene delivery system for cancer immunotherapy. | en |
dc.description.sponsorship | Ministry of Science and Technology in Korea
(M10414030002-05N1403-00210; T.H. Kim and C.S. Cho) and Nano Systems Institute-National Core Research Center (H. Jin, H.W. Kim, and M.H. Cho). H. Jin and H.W. Kim are recipients of a BK21 fellowship. | en |
dc.language.iso | en | en |
dc.publisher | American Association for Cancer Research | en |
dc.subject | cytokine gene therapy | en |
dc.subject | IL-12 | en |
dc.subject | mannosylated chitosan nanoparticle | en |
dc.subject | dendritic cells | en |
dc.title | Mannosylated chitosan nanoparticle–based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김태희 | - |
dc.contributor.AlternativeAuthor | 김현우 | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.contributor.AlternativeAuthor | 조종수 | - |
dc.identifier.doi | 10.1158/1535-7163.MCT-05-0540 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.