Potentiation of porcine circovirus 2-induced postweaning multisystemic wasting syndrome by porcine parvovirus is associated with excessive production of tumor necrosis factor-alpha

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Kim, J.; Ha, Y.; Chae, Chan Hee
Issue Date
American College of Veterinary Pathologists
Vet Pathol 43:718-725, 2006
Porcine circovirusporcine parvoviruspostweaning multisystemic wasting syndromeswinetumor necrosis factor-a
This study investigated the potentiation of porcine circovirus 2 (PCV2)-induced
postweaning multisystemic wasting syndrome by porcine parvovirus (PPV) and found it was associated
with excessive production of tumor necrosis factor-a (TNF-a). Colostrum-deprived conventional pigs
were inoculated intranasally with PCV2 or PPV alone or in combination (PCV2 and PPV). In vitro assay
of TNF-a, obtained from alveolar macrophages coinfected with PCV2 and PPV, showed a significant
increase in TNF-a compared to single infection of macrophages with either PCV2 or PPV alone (P ,
0.05). All pigs inoculated with PCV2 and PPV developed severe postweaning wasting syndrome, whereas
clinical signs (e.g., weight loss) were present but perhaps less severe in either PCV2- or PPV-inoculated
pigs. Compared to the pigs inoculated with PCV2 or PPV alone, pigs inoculated dually with PCV2 and
PPV showed significantly (P , 0.05) increased levels of TNF-a. Levels of TNF-a in the sera were
reversely correlated with the body weight in pigs experimentally infected with dual inoculation of PCV2
and PPV (rs 5 20.92, P , 0.001). These data suggest that a potentiation of PPV in PCV2-induced
PMWS is associated with the excessive production of TNF-a.
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