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Carcinoembryonic Antigen (CEA) in N-methyl-N'-nitro-N-nitrosoguanidine-Induced Gastrointestinal Carcinomas of the Rats
N-methyl-N'-nitro-N-nitrosoguanidine 투여에 의한 실험적 상부 소화관 암종의 암태생항원 발현에 관한 면역조직화학적 관찰

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Authors
Kim, Woo Ho; Kim, Yong Il; Han, Duck Jong; Kim, Jin-Pok
Issue Date
1987-12
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1987;28(4):297-301
Keywords
N-methyl-N'-nitro-N-nitrosoguanidineExperimental carcinomaGastrointestinal carcinomaImmunohistologic carcinoembryonic antigen
Abstract
Immunohistologic findings on carcinoembryonic antigen (CEA) and its serum
level were compared in N-methyl-N' -nitro-N-nitrosoguanidine (MNNG)-induced gastrointestinal
malignant tumors. Of fifty-six malignant neoplastic lesions developed from 39 rats, only
10 carcinomas were CEA positive (10.7% of gastric and 31.8% of small intestinal cancers) in
cytoplasm of tumor cells by peroxidase-antiperoxidase (PAP) staining method. Animals with
CEA positive carcinoma showed the highest level of serum CEA than any other groups, but
the difference was not statistically significant (0.964 ± 0.150 versus 0.883 ±0.094). The
above findings lead to the suggestion that experimental gastric carcinoma expresses lower CEA
positivity than intestinal carcinoma, comparatively similar to the reported results in human
cases.
ISSN
0583-6802
Language
English
URI
http://hdl.handle.net/10371/6552
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 28 No.4 (1987)
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