첨가 동종 타액선조직의 반복주사에 의한 백서 타액선염에 관한 실험적 연구
An Experimental Study on Sialadenitis in Rats Induced by Repeated Injections of Homologous Sal vary Gland with Freund's Complete Adjuvant

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서정익; 이제구
Issue Date
서울대학교 의과대학
Seoul J Med 1971;12(4):243-257
A study of experimental sialadenitis was carried
out by means of repeated injections of homologous
salivary gland suspension with Freund's complete
adjuvant in rats, as an attempt to produce immunerelated
sialadenitis and to clarify the nature of this
type of lesion, in relation to Sjogren's syndrome and
certain chronic non-specific sialadenitis.
The results were as follows:
1. A significant inflammatory change of salivary
gland was observed in the group of animals for which
homologous salivary gland suspension with Freund's
complete adjuvant was injected. Significant sialadenitis
was evident in 9 mucous glands and 14 serous
glands of 15 animals, respectively. The major histologic
alterations included atrophy and degeneration of
acini with occasional intraluminal inspissation of
secretory substance, duct ectasia with or without
stagnation of inspissated secretion, and focal or diffuse
infiltration of lymphocytes, pseude-eosinophils, plasma cells and histiocytes with a rare lymphoid follicle
formation, the latter assuming roughly correlated with
severity of the formers.
2. Less apparent inflammatory change was demonstrated
in the animal groups for which salivary gland
suspension was given alone than those added with
Freund's complete adjuvant.
3. The other animal groups exhibited no significant
sialadenitis or evidence of cross-reaction in other
4. Two types of changes were observed in groups
of animals received either adjuvant alone or with
tissue suspension, the one is non-caseating granuloma
formation in the injected site of skin, lung and
liver; the another is marked hyperplasia of reticuloendothelial
cells of spleen, lungs, and liver with enhanced
infiltration of plasma cells and lymphocytes.
From the above histopathologic findings, the experimental
sialadenitis presently described shows many
similarity to those of Sjogren's syndrome and/or certain
chronic non-specific sialadenitis, and it is assumed
that an immunological process may be considered as
one of the pathogenetic pathways of Sjogren's syndrome
or certain chronic sialadenitis.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 12 No.4 (1971)
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