전기충격이 백서대뇌조직의 Alkaline Ribonuclease 및 Ribonuclease Inhibitor활성에 미치는 영향

Abstract

Studies were conducted on the effects of electroconvulsive shock (lOOV, A.C. 2 sec, transaurally) upon the contents of DNA, RNA, protein and the activities of alk. RNase inhibitor in the cerebral tissues of the albino rats. The contents of DNAand protein were not affected, but those of RNA were decreased significantly after the ECS. And the activities of free alk.RNase were increased, while those of total alk. RNase were not increased after the ECS. This fact may suggest that the alk. RNase inhibitor might be vulnerable to ECS, and the alteration of RNase-Inhibitor system could be involved in one of possible biochemical mechanisms for the retrograde amnesia induced by ECS.