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Diphenylhydantoin(DPH)이 심실근의 수축 및 활동전압에 미치는 영향
Effect of Diphenylhydantoin(DPH) on Elcctrophysiological property of rabbit papillary muscle

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Authors
최용
Issue Date
1980-03
Publisher
서울대학교 의과대학
Citation
Seoul J Med 1990;21(1):14-20
Abstract
The effects of diFhenylhyc€ntoin(DPH) en the : mechanical and electrical responses of rabbit papillary
muscles were studied with conventional micro'
electrode technique.
1. The resting membrane potential of the rabbit
papillary muscle was -85~-80mV, the duration of
action potnetial 150~200msec, and Vmax 600v/s in
normal Tyrode solution.
2. DPH did not change resting membrane potential
and amplitude of action potential, but the duration
of 50% repolarization was decreased to 93. 5±2. 5,
93. 8±1. 6 and 87. 5±1. 2% of normal in 3, 10, 30mg/l
-of DPH respectively. Vmax, after adding DPH, was
increased to 130±2.4, 130±3.2 and 121. 6±2. 8%
·of normal in 3,10, 30mg/l, and it was more prominent
in lower concentrations of DPH.
3. In partially depolarized muscle by 18mM-K, the
.amplitude of action potential was decreased to 90.5
±1. 3, 89. 0±2. 5 and 83. 3±1. 7%, and the duration
of action potential was similarly decreased to 89. 2±
.2.1, 78. 5±1. 8 and 75. 0±1. 0% of the control at the
concentration of 3,10, 30mg/l of DPH, respectively.
4. Contractility was decreased in both normal and
K·Tyrode solution by DPH and it was dose-dependent,
The above results suggested that the shortening of
action potential duration and negative inotropic effect
of DPH were mainly due to decreased slow inward
current, especially calcium current.
Language
Korean
URI
http://hdl.handle.net/10371/6647
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 21 No.1 (1980)
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