급성 일산화탄소 중독이 백서 폐의 Clara세포에 미치는 영향에 관한 연구
The Clara Cells in Acute Carbon Monoxide Poisoning Rats

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함의근; 송계용
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서울대학교 의과대학
Seoul J Med 1980;21(2):138-145
The authors report light microscopic and histochemical
studies on the Clara cells of the terminal
bronchioles in acute carbon monoxide poisoning rats.
And, moreover, the morphologic features of the Clara
cells and its population changes in the terminal
bronchioles following short term exposure to carbon
monoxide were observed.
The nonciliated bronchiolar epithelial cells (the
Clara cells) were responded to acute carbon monoxide
poisoning as an acceleration of prominent extrusion
of the apical caps and resulted in apocrine secretion
into the terminal bronchiole as well as significant
decrease of their numbers in lobal distribution by
45 to 60 minutes (peX') <0. 01). And by the 2
hours, there was slight degree of compensation,
similar to that seen in tl e acute hypoxia caused a
deficiency of pulmonary surfactant.
The results of this study indicated that the Clara
cells were actively metabolic and has apocrine
secretory function, which might be related to the
pulmonary surfactant mechanism.
(This study was supported in part by the research
grant(C.M.B. 74-332-5), the China Medical Board
of New York. This paper was read at the 4th Asia
Pacific Congress on Disease of the Chest.)
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 21 No.2 (1980)
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