Browse

Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Kim, Juyang; Choi, Sun Phil; La, Soojin; Seo, Jeong-Sun; Kim, Kack Kyun; Nam, Seok Hyun; Kwon, Byungsuk
Issue Date
2003-12-31
Publisher
Korean Society of Medical Biochemistry
Citation
Experimental and Molecular Medicine 2003;35(6):509-17
Keywords
antigens, CD4antigens, differentiationcytokinesT lymphocyteT lymphocyte, hyper-inducerT lymphocyte subsets
Abstract
4-1BB, a transmembrane molecule, member of the
tumor necrosis factor receptor superfamily, is an
im portant costim ulatory molecule in the immune
response, plays a key role in the clonal expansion
and survival of CD8+ T cells. In this study, we investigated
4-1BB regulation of CD4+ T cell responses
using 4-1BB transgenic (TG) mice that
constitutively expressed 4-1BB on mature T cells.
We first showed that CD4+ T cells of 4-1BB TG
mice had more sustained proliferative capacity in
response to TCR/4-1BB stimulation in vitro compared
to WT mice. Secondly, 4-1BB TG mice
exhibited a more elevated contact hypersensitivity
(CHS) response mediated by CD4+ Th1 cells due
to more vigorous expansion of and apoptotic
inhibition of CD4+ T cells. Finally, CD4+ T cells of
4-1BB TG mice had a heightened capacity for T
cell prim ing. Overall, our results demonstrate the involvement of 4-1BB in CD4+ Th1 cell responses
by regulating the clonal expansion and survival of
CD4+ T cells as seen in CD8+ T cells.
ISSN
1226-3613
Language
English
URI
http://hdl.handle.net/10371/66618
Files in This Item:
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse