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Correlation of immunohistochemical characteristics of the craniomandibular joint with the degree of mandibular lengthening in rabbits

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Authors
Kim, Su-Gwan; Park, Ju-Cheol; Kang, Dong-Wan; Kim, Byung-Ock; Yoon, Jung-Hoon; Cho, Se-Inn; Choe, Han-Cheol; Bae, Chun-Sik
Issue Date
2003-10
Publisher
Elsevier
Citation
J Oral Maxillofac Surg 61:1189-1197
Abstract
Purpose: This study examined immunohistochemical changes in the craniomandibular joints of rabbits
after distraction osteogenesis following mandibular corticotomy.
Materials and Methods: The experimental animals (n 8) were divided into 3 groups that underwent
2, 3.5, and 5 mm of unilateral distraction osteogenesis (groups 1, 2, and 3, respectively). After
corticotomy of the left mandibular body and a 7-day healing period, a second operation was performed
to expose the device. Distraction was then performed at the rate of 0.5 mm/d. A 14-day consolidation
period was allowed after the distraction was complete. Changes in cartilage, osteoblast activity, and
osteoclast activity were then examined.
Results: The differentiation and proliferation of cartilage increased in groups 1 and 2, were highest in group
2, and decreased in group 3. Group 2 also showed the greatest increase in the width of the hypertrophic
chondrocyte layer. Relative to the control group, osteoclast activity was only somewhat higher in groups 1
and 2 but was significantly higher in group 3. Osteoblast activity was significantly higher in groups 1 and 2
than in the control group. However, the osteoblast activity in group 3 was slightly lower than that in group
2. At the time of unilateral mandibular distraction, no degenerative changes of the temporomandibular joint
were observed in groups 1 or 2, but bone resorption was observed in group 3.
Conclusions: The unilateral mandibular distraction of 2 or 3.5 mm was acceptable in that no degenerative
changes of the temporomandibular joint were observed on either the distraction or the nondistraction sides.
Five millimeters of distraction might be beyond physiologic limits.
ISSN
0278-2391
Language
English
URI
http://hdl.handle.net/10371/66622
DOI
https://doi.org/10.1016/S0278-2391(03)00681-5
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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