Roles of Monoamine Neurotransmitters in the Regulation of Hypothalamic-Pituitary-Adrenal Axis (HPA) (II) - Role of 5-H'ydroxytryptamine(Serotonin) in Controlling the Circadian Rhythmicity of Corticosterone in Rat

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Suh, Yoo Hun; Park, Chan Woong
Issue Date
서울대학교 의과대학
Seoul J Med 1983;24(1):82-90
Various pharmacologic studies have supported
a stimulatory role of brain serotonin neurons in
the hypothalamic regulation of circadian rhythmicity
of pituitary-adrenocortical system in rats.
The serotonin precursors (Lvtryptophan and
L-5-hydroxytryptophan) , direct acting serotonin
agonist C5-Methoxy-N-N-dimethyltryptamine)
and monoamine oxidase inhibitor (Pargyline)
all elevate both morning and evening plasma
corticosterone levels in rats. The elevation of
plasma corticosterone by L-tryptophan (lOOmg/
kg) was potentiated by monoamine oxidase
inhibitor, pargyline C70mg/kg). The elevation
of plasma corticosterone by 5-hydroxytryptophan
and 5-methoxy-N-N-dimethyl tryptamine showed
a dose-related fashion both in the morning
and in the evening.
Serotonin synthesis inhibitor (Pv chlorophenyialanine)
and serotonin neurotoxin(5,7-dihydroxy
tryptamine) caused a fall in plasma corticosterone
Daily injections of p-chlorophenylalanine (300
mg/kg/day) for 2 days raised the morning low
and prevented the evening rise in plasma corticosterone.
The evening rise in plasma corticosterone
was restored by the injection of 5-hydroxytryptophan
and 5-methoxy-N-N-dimethyltryptamine.
There was a positive correlation between the
concentrations of serotonin in the hypothalamus
and the concentrations of plasma corticosterone
caused by various pharmacologic manipulation.
Thus, our studies suggested that brain serotoninergic
neurons may play an important role
in the regulation of the diurnal rhythmicity of
adrenocortical function.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 24 No.1 (1983)
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