이식 신의 급성 거부 반응에 있어서 99mTc-DTPA 신스캔의 진단적 가치에 관한 연구
A Study on the ggm Tc-DTPA Renal Scan in Acute Rejection of Transplanted kidney.

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고창순; 박정식; 표희정; 김성권; 이명철; 조보연; 이정상
Issue Date
서울대학교 의과대학
Seoul J Med 1983;24(1):97-105
In order to assess the usefulness of 09mTc·DTPA
renal scan in diagnosing acute rejection renal graft,
we performed 87 studies on 26 renal graft recipients.
All the grafts except one were transplanted from
living donors. The majority of the studies were made
during the early posttransplantation period. At the
time of scanning, the retrospectively confirmed clin·
ical assessment of the graft function was normal in
75 studies, acute rejection in 10, acute tubular
necrosis in one and renal artery stenosis in the
As well as data obtained from scintillation camera
images, computer-drived time-activity curves of renal
perfusion were analyzed using 4 different parameters-
aortorenal transit time. peak to plateau ratio,
perfusion index, and T1/2 of washout phase.
The perfusion curve of normal functioning kidney
showed sharp peak follow by rapid declination of
radioactivity. But the curve of acute rejection showed
low, blunted peak and delayed washout in all cases, whereas that of acute tubular necrosis was relatively
normal. Among the 4 perfusion parameters, Tl/2
revealed the highest diagnostic sensitivity (100%),
that is, it was increased over 20 sec. in all acute
rejection cases. And its specificity is 93.296.
From the above results, we concluded that cornputer-
processed 9OmTc·DTPA renal scan was useful in
diagnosing acute rejection of transplanted kidney.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 24 No.1 (1983)
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