SHERP

Direct Effects of Amide-Type Local Anesthetics on Isolated Rat Ventricular Papillary Muscles
Lidocaine과 bupivacaine이 쥐의 좌심유두근에 미치는 직접적 효과에 관한 비교연구

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Authors
Lee, Sang Chul
Issue Date
1991-06
Publisher
Seoul National University College of Medicine
Citation
Seoul J Med 1991;32(2):83-90
Keywords
AmideLocal AnestheticLidocaineBupivacaineCardiodepression
Abstract
The direct effects of 2 amide-type local anesthetics, lidocaine and bupivacaine,
on myocardial contractility were studied in isolated rat heart muscles. Three
different clinically equipotent doses of each agent were tested. In Tpd, +dp/dtmax,
and - dp/dt-,», the cardiodepressive action of lidocaine seemed to be slightly more
than that of bupivacaine, but bupivacaine showed a more depressive action on myocardial
contractility from the results of Tr and RT90%. We might say that lidocaine exhibit
significant cardiodepressive activity, which is at least similar with bupivacaine.
ISSN
0582-6802
Language
English
URI
http://hdl.handle.net/10371/6732
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)The Seoul Journal of MedicineThe Seoul Journal of Medicine Vol. 32 No.2 (1991)
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