Browse

Low-dose etanercept therapy in moderate to severe psoriasis in Korean

Cited 15 time in Web of Science Cited 16 time in Scopus
Authors
Na, Jung Im; Kim, Jun Hyung; Park, Kyoung Chan; Youn, Sang Woong
Issue Date
2008-09-16
Publisher
Wiley-Blackwell
Citation
Journal of Dermatology 2008; 35(8): 484-490
Keywords
Anti-Inflammatory Agents, Non-Steroidal/*administration & dosageAsian Continental Ancestry GroupFemaleHumansImmunoglobulin G/*administration & dosageImmunosuppressive Agents/*administration & dosageMalePsoriasis/*drug therapyReceptors, Tumor Necrosis Factor/*administration & dosageRetrospective StudiesSeverity of Illness IndexTreatment Outcome
Abstract
Etanercept is a fully humanized soluble tumor necrosis factor (TNF)-alpha receptor that competitively inhibits the interaction of TNF-alpha with cell-surface receptors. It was approved as monotherapy for psoriasis in the USA in 2004, but in Korea, no clinical reports on its use for psoriasis are available. We performed a retrospective analysis of 26 moderate-to-severe psoriasis patients who had been treated with etanercept. Patients received twice-weekly injections of 25 mg etanercept s.c. for at least 4 weeks. When the patients achieved a 50% reduction of the psoriasis area severity index (PASI 50) they received once-weekly injections, then biweekly injections were provided for maintenance. Patients were evaluated biweekly by clinical photographs and PASI scoring. Treatment efficacy was as follows. A PASI 75 was achieved in 14 patients (54%) and the mean number of injections before achieving a PASI 75 was 10 +/- 7.5. Patients whose initial PASI was less than 10 (iPASI < 10) showed an earlier response (2.6 +/- 1.3 weeks) and a higher PASI 75 rate (63%), than with iPASI > or = 10 (6.9 +/- 4.5 weeks, 50%). Eight patients (31%) received additional phototherapy or systemic therapy because of insufficient responses or for faster improvements and they were excluded in the efficacy evaluation. Adverse events were observed in eight patients (31%), but were not serious. This is the first report on the effectiveness of low-dose etanercept regimen on Asian psoriasis patients. Results in this study showed that low-dose etanercept therapy is effective for moderate-to-severe Asian psoriasis patients, and it may be a valuable treatment option even for relatively moderate psoriasis patients not responsive to conventional treatment. In addition, the medical cost was relatively low compared to that of the standard regimen for white patients.
ISSN
0385-2407 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18789067

http://hdl.handle.net/10371/67521
DOI
https://doi.org/10.1111/j.1346-8138.2008.00508.x
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse