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Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sangmin | - |
dc.contributor.author | Kim, Yoonkyung | - |
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Cho, Kwang Hyun | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.date.accessioned | 2010-06-07T04:45:46Z | - |
dc.date.available | 2010-06-07T04:45:46Z | - |
dc.date.issued | 2007-10-24 | - |
dc.identifier.citation | Phytomedicine. 15(5), 340-347 | en |
dc.identifier.issn | 1618-095X (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17951041 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B7GVW-4PYYG36-2-9&_cdi=20441&_user=168665&_orig=search&_coverDate=05%2F15%2F2008&_sk=999849994&view=c&wchp=dGLbVzW-zSkWb&md5=c8a35aac76283ba4a29071482dfdf0a7&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67531 | - |
dc.description.abstract | Berberine is a plant ingredient that has anti-inflammatory and anti-oxidative effects. Matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) are known to be highly induced by ultraviolet (UV) light and may play important roles in UV-induced skin inflammation and the skin aging process. In this study, we investigated the effects of berberine on MMP-9 and IL-6 expression in normal human keratinocytes (NHK). Our results demonstrated that berberine dose-dependently inhibited basal and TPA-induced expression and activity of MMP-9, and also suppressed TPA-induced IL-6 expression. Berberine prevented TPA-induced ERK activation and AP-1 DNA binding activity. Therefore, berberine may be used as an effective ingredient for anti-skin aging products, which can prevent skin inflammation and the degradation of extracellular matrix proteins, including collagen, by MMPs. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Berberine/chemistry/*pharmacology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Gene Expression Regulation/drug effects | en |
dc.subject | Humans | en |
dc.subject | Interleukin-6/*antagonists & inhibitors/genetics/metabolism | en |
dc.subject | Keratinocytes/*drug effects/metabolism | en |
dc.subject | Matrix Metalloproteinase 9/*antagonists & inhibitors/genetics/metabolism | en |
dc.subject | Molecular Structure | en |
dc.subject | Pyridines/*toxicity | en |
dc.title | Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김상민 | - |
dc.contributor.AlternativeAuthor | 김윤경 | - |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1016/j.phymed.2007.09.011 | - |
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