Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: a double-blind, placebo-controlled study

Abstract

Many studies have suggested that food additives are associated with dermatologic adverse reactions, such as urticaria, angioedema,and the aggravation of pre-existing atopic dermatitis symptoms. However, results of previous investigations to evaluate a causative relationship between food additives and dermatologic adverse reactions were discrepant. Some favored such a relation,1-3 but others did not.4-6 These problems need to be settled by a vigorously controlled and well conducted challenge.