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Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts
Cited 9 time in
Web of Science
Cited 9 time in Scopus
- Authors
- Issue Date
- 2008-06-19
- Publisher
- Wiley-Blackwell
- Citation
- Exp Dermatol. 2008; 17(11): 939-945
- Keywords
- Adenoviridae/genetics ; Benzothiazoles/pharmacology ; Blotting, Western ; Cells, Cultured ; Dermis/cytology/metabolism ; Etoposide/pharmacology ; Fibroblasts/drug effects/*metabolism/radiation effects ; Humans ; Matrix Metalloproteinase 1/*metabolism ; Phosphorylation/drug effects/radiation effects ; Proto-Oncogene Proteins c-fos/metabolism ; Proto-Oncogene Proteins c-jun/metabolism ; Toluene/analogs & derivatives/pharmacology ; Transduction, Genetic ; Tumor Suppressor Protein p53/genetics/*physiology ; Young Adult ; Ultraviolet Rays
- Abstract
- Ultraviolet (UV) triggers induction of matrix metalloproteinase-1 (MMP-1) and also induces the rapid appearance of p53 protein in the epidermis and dermal fibroblasts. However, little is known about the role of p53 on MMP-1 expression in human skin. Here, we investigated the effects of p53 on basal and UV-induced MMP-1 in human dermal fibroblasts. To verify the role of p53 on MMP-1 expression, adenoviral p53 (Ad-p53) gene was infected to human dermal fibroblasts. Our results showed that basal and UV-induced MMP-1 expression was prevented by Ad-p53. In contrast, p53 inhibitor, pifithrin-alpha augmented the UV-induced MMP-1 expression. On the other hand, p53 activator, etoposide, decreased the MMP-1 expression in both normal and p53-overexpressed cells. In addition, MMP-1 expression was not changed by etoposide and/or pifithrin-alpha in HaCaT cells, which have mutation of p53. Taken together, we suggest that p53 inhibits basal and UV-induced MMP-1 expression in human dermal fibroblasts.
- ISSN
- 1600-0625 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18557930
https://hdl.handle.net/10371/67537
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