S-Space College of Dentistry/School of Dentistry (치과대학/치의학대학원) Dept. of Dentistry (치의학과) Journal Papers (저널논문_치의학과)
Expression of volume-activated anion channels in exocrine acinar cells
- Park, Kyungpyo; Majid, Aneela
- Issue Date
- Korean Academy of Medical Sciences
- Journal of Korean Medical Science 2000; 15: S61-S62
- Volume-sensitive anion channels (Iclswell)are expressed in most mammalian cells (1). The molecular identity of Iclswell is not known, however, several candidate proteins have been proposed including: p-glycoprotein, pIcln, CIC-2 and CIC-3(2). The properties of CIC-3 make it one of the most likely candidate proteins, e.g. it has a structure which is very similar to that of know Cl- channels (CIC-0 and CIC-1), and it produces an outward-rectifying Cl- conductance when expressed in Xenopus oocytes or mammalian cell lines (3).