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Role of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomy

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dc.contributor.authorChung, Hyun Hoon-
dc.contributor.authorPark, Noh-Hyun-
dc.contributor.authorKim, Jae Weon-
dc.contributor.authorSong, Yong-Sang-
dc.contributor.authorChung, June-Key-
dc.contributor.authorKang, Soon-Beom-
dc.date.accessioned2010-06-24T05:18:46Z-
dc.date.available2010-06-24T05:18:46Z-
dc.date.issued2008-10-10-
dc.identifier.citationGynecol Obstet Invest. 2009;67(1):61-66en
dc.identifier.issn1423-002X (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18843187-
dc.identifier.urihttp://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000162101&Ausgabe=239980&ProduktNr=223845&filename=000162101.pdf-
dc.identifier.urihttp://hdl.handle.net/10371/67778-
dc.description.abstractBACKGROUND: To investigate the feasibility of preoperative integrated positron emission tomography-computed tomography (PET-CT) with fluoro-2-deoxy-D-glucose (FDG) in primary pelvic lymph node (LN) staging before radical hysterectomy (RH) and pelvic lymphadenectomy (PLND) in cervical cancer. METHODS: We reviewed medical records of all patients with FIGO stage IA2-IIB cervical cancer who underwent a preoperative FDG PET-CT and underwent type II or III RH and PLND between January 1, 2003, and July 31, 2007. RESULTS: A total of 34 patients underwent preoperative PET-CT scans followed by RH and PLND during the study period. Of the 34 patients, 17 (50.0%) had pelvic LN metastases, and the median number of harvested LNs was 29 (range 13-57). The overall region-specific sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET-CT were 36.4, 98.8, 85.7, 88.9, and 88.7%, respectively. The patients with positive preoperative PET-CT scans showed higher recurrence rates (3/8) than those with negative scans (1/26); the difference was statistically significant (p = 0.031). CONCLUSION: Integrated PET-CT scan has limited sensitivity, but high specificity for predicting pelvic LN metastasis in preoperative staging of invasive cervical cancer. Furthermore, preoperative integrated PET-CT may be a useful tool for identifying patients with higher risk of cervical cancer recurrence.en
dc.language.isoen-
dc.publisherKargeren
dc.subjectAdulten
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHysterectomyen
dc.subjectLymph Node Excisionen
dc.subjectLymph Nodes/*pathology/radionuclide imaging/surgeryen
dc.subjectLymphatic Metastasisen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPositron-Emission Tomography/*methodsen
dc.subjectPredictive Value of Testsen
dc.subjectReproducibility of Resultsen
dc.subjectRetrospective Studiesen
dc.subjectSensitivity and Specificityen
dc.subjectTomography, X-Ray Computed/*methodsen
dc.subjectUterine Cervical Neoplasms/*pathology/radionuclide imaging/surgeryen
dc.titleRole of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomyen
dc.typeArticleen
dc.contributor.AlternativeAuthor정현훈-
dc.contributor.AlternativeAuthor박노현-
dc.contributor.AlternativeAuthor김재원-
dc.contributor.AlternativeAuthor송용상-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor강순범-
dc.identifier.doi10.1159/000162101-
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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