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Role of integrated PET-CT in pelvic lymph node staging of cervical cancer before radical hysterectomy
Cited 28 time in
Web of Science
Cited 28 time in Scopus
- Authors
- Issue Date
- 2008-10-10
- Publisher
- Karger
- Citation
- Gynecol Obstet Invest. 2009;67(1):61-66
- Keywords
- Adult ; Aged ; Female ; Humans ; Hysterectomy ; Lymph Node Excision ; Lymph Nodes/*pathology/radionuclide imaging/surgery ; Lymphatic Metastasis ; Middle Aged ; Neoplasm Staging ; Positron-Emission Tomography/*methods ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed/*methods ; Uterine Cervical Neoplasms/*pathology/radionuclide imaging/surgery
- Abstract
- BACKGROUND: To investigate the feasibility of preoperative integrated positron emission tomography-computed tomography (PET-CT) with fluoro-2-deoxy-D-glucose (FDG) in primary pelvic lymph node (LN) staging before radical hysterectomy (RH) and pelvic lymphadenectomy (PLND) in cervical cancer. METHODS: We reviewed medical records of all patients with FIGO stage IA2-IIB cervical cancer who underwent a preoperative FDG PET-CT and underwent type II or III RH and PLND between January 1, 2003, and July 31, 2007. RESULTS: A total of 34 patients underwent preoperative PET-CT scans followed by RH and PLND during the study period. Of the 34 patients, 17 (50.0%) had pelvic LN metastases, and the median number of harvested LNs was 29 (range 13-57). The overall region-specific sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of PET-CT were 36.4, 98.8, 85.7, 88.9, and 88.7%, respectively. The patients with positive preoperative PET-CT scans showed higher recurrence rates (3/8) than those with negative scans (1/26); the difference was statistically significant (p = 0.031). CONCLUSION: Integrated PET-CT scan has limited sensitivity, but high specificity for predicting pelvic LN metastasis in preoperative staging of invasive cervical cancer. Furthermore, preoperative integrated PET-CT may be a useful tool for identifying patients with higher risk of cervical cancer recurrence.
- ISSN
- 1423-002X (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18843187
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000162101&Ausgabe=239980&ProduktNr=223845&filename=000162101.pdf
https://hdl.handle.net/10371/67778
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