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Screening CT colonography in an asymptomatic average-risk Asian population: a 2-year experience in a single institution

Cited 24 time in Web of Science Cited 26 time in Scopus
Authors
An, Sangbu; Lee, Kyoung Ho; Kim, Young Hoon; Park, Seong Ho; Kim, Hyun Young; Kim, Se Hyung; Kim, Nayoung
Issue Date
2008-08-22
Publisher
American Roentgen Ray Society
Citation
AJR 2008; 191(3):W100-W106
Keywords
AdultAgedAged, 80 and overColonic Polyps/*epidemiology/*radiographyColonography, Computed Tomographic/*statistics & numerical dataFemaleHumansIncidenceKorea/epidemiologyMaleMass Screening/*statistics & numerical dataMiddle AgedReproducibility of ResultsRisk Assessment/*methodsRisk FactorsSensitivity and Specificity
Abstract
OBJECTIVE: The purpose of our study was to report the results of screening CT colonography (CTC) in an asymptomatic average-risk Asian population. MATERIALS AND METHODS: In 2005 and 2006, 1,015 Korean adults (609 men and 406 women; mean age, 51 years) underwent screening CTC using a 16-MDCT scanner and an automated CO2 delivery system. During the study period, the protocols were changed to use less vigorous purgation and lower radiation doses; fecal tagging (n = 890) and primary 3D interpretation (n = 966) were generally used. CTC results were categorized as C0, inadequate; C1, no significant polyp; C2, one or two 6- to 9-mm polyps; C3, polyps > or = 10 mm or > or = three 6- to 9-mm polyps; and C4, mass. Patients with positive CTC results were referred to gastroenterologists for follow-up or management planning. RESULTS: Categories C0-C4 were assigned to 21 (2.1%), 916 (90.2%), 54 (5.3%), 23 (2.3%), and one (0.1%) patients, respectively. Fifty-four patients with C4 (n = 1), C3 (n = 20), or C2 (n = 33) underwent subsequent optical colonoscopy: complete (n = 53) and incomplete (n = 1). Per-patient positive predictive values (PPVs) for categories C3-C4 and C2-C4 were 90% (18/20) and 74% (39/53), respectively. Per-polyp PPVs at 10- and 6-mm thresholds were 92% (22/24) and 69% (45/65), respectively. The diagnostic yield for advanced neoplasm was 1.5% (15/1,015). CONCLUSION: Our results seem comparable to Western experiences, showing that a successful screening CTC program can be reproduced in an Asian population.
ISSN
1546-3141 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18716076

http://www.ajronline.org/cgi/reprint/191/3/W100.pdf

http://hdl.handle.net/10371/67785
DOI
https://doi.org/10.2214/AJR.07.3367
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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