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Hepatitis a in Korea: epidemiological shift and call for vaccine strategy

Cited 44 time in Web of Science Cited 44 time in Scopus
Authors
Lee, Donghun; Cho, Young-Ae; Park, Youngsoo; Hwang, Jin-Hyuk; Kim, Jin Wook; Kim, Na Young; Lee, Dong Ho; Lee, Wonwoo; Jeong, Sook-Hyang
Issue Date
2008-04-25
Publisher
Karger
Citation
Intervirology. 2008;51(2):70-74
Keywords
AdolescentAdultChildChild, PreschoolFemaleHepatitis A/*epidemiology/physiopathology/prevention & controlHepatitis A Antibodies/*bloodHepatitis A Vaccines/administration & dosageHepatitis A Virus, Human/*immunologyHospitalizationHumansInfantKorea/epidemiologyMaleMiddle AgedSeverity of Illness IndexVaccination
Abstract
OBJECTIVE: The number of adult hepatitis A cases has progressively been increasing during the last several years in Korea. The aim of the present study was to describe the recent clinical features of hepatitis A and the seroprevalence of hepatitis A virus (HAV), and to discuss HAV vaccine strategy in Korea. METHODS: Retrospective analysis of clinical characteristics of hepatitis A from 109 patients consecutively enrolled at a community hospital between 2003 and 2006 as well as cross-sectional study of seroprevalence of HAV from 307 patients of hospital population group during the same period were performed. RESULTS: Most hepatitis A cases were young adults in their twenties or thirties, and the severity of the disease was related to the age of patients. The seroprevalence of HAV was 62%, which was dependent on the age of patients. HAV seroepidemiology in Korea is rapidly changing and a growing number of young adults are susceptible to HAV infection. CONCLUSIONS: The clinical features and the epidemiological shift of HAV urge Korea, as well as other countries which are experiencing similar issues, to promote childhood vaccination and consider catch-up vaccination for adolescents and young adults.
ISSN
1423-0100 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18434743

http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000127428&Ausgabe=237337&ProduktNr=224031&filename=000127428.pdf

http://hdl.handle.net/10371/67796
DOI
https://doi.org/10.1159/000127428
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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