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Loss of asymmetry in D2 receptors of putamen in unaffected family members at increased genetic risk for schizophrenia

Cited 12 time in Web of Science Cited 14 time in Scopus
Authors
Lee, K J; Lee, J S; Kim, S J; Correll, C U; Wee, H; Yoo, S Y; Jeong, J M; Lee, D S; Lee, S I; Kwon, J S
Issue Date
2008-08-14
Publisher
Wiley-Blackwell
Citation
Acta Psychiatr Scand. 2008;118(3):200-208
Keywords
AdolescentAdultBrain/physiopathology/radionuclide imagingCognition Disorders/diagnosis/genetics/psychologyFamily/*psychologyFemaleFunctional Laterality/*geneticsGenetic Markers/geneticsGenetic Predisposition to Disease/*psychologyHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleNeuropsychological Tests/statistics & numerical dataPositron-Emission Tomography/methodsPutamen/*physiopathologyReceptors, Dopamine D2/*geneticsSchizophrenia/*geneticsYoung Adult
Abstract
OBJECTIVE: Dopamine dysregulation has been implicated in the pathophysiology of schizophrenia. The present study was performed to examine whether unaffected relatives at high genetic risk of schizophrenia have dopamine dysregulation in comparison with healthy controls. METHOD: Eleven unaffected relatives from families with two or more first- or second-degree relatives with schizophrenia (n = 9) or with a monozygotic schizophrenic twin (n = 2) and 11 age- and sex-matched controls were examined using positron emission tomography (PET) with [(11)C] raclopride. Subjects also underwent extensive neuropsychological testing. RESULTS: Subjects with high genetic risk showed a loss of asymmetry of D(2) receptors in the putamen in comparison with healthy controls. In addition, they showed significantly poorer performance on neuropsychological tests than controls. CONCLUSION: Our results suggest that dopamine dysregulation and neuropsychological dysfunction may be present in subjects at high genetic risk of schizophrenia. However, further studies are required to confirm these findings.
ISSN
1600-0447 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18699953

http://hdl.handle.net/10371/67807
DOI
https://doi.org/10.1111/j.1600-0447.2008.01223.x
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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