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BT-11 improves stress-induced memory impairments through increment of glucose utilization and total neural cell adhesion molecule levels in rat brains

Cited 32 time in Web of Science Cited 36 time in Scopus
Authors
Shin, Ki Young; Won, Beom Young; Heo, Chaejeong; Kim, Hee Jin; Jang, Dong-Pyo; Park, Cheol Hyoung; Kim, Seonghan; Kim, Hye-Sun; Kim, Young-Bo; Lee, Hyung Gun; Lee, Sang Hyung; Cho, Zang-Hee; Suh, Yoo-Hun
Issue Date
2008-08-21
Publisher
Wiley-Blackwell
Citation
J Neurosci Res. 87(1):260-268
Keywords
AnimalsAvoidance Learning/drug effectsBrain/drug effects/*metabolism/radionuclide imagingCyclohexylamines/therapeutic useDisease Models, AnimalExploratory Behavior/drug effectsFluorodeoxyglucose F18/metabolismGlucose/*metabolismMaze Learning/drug effectsMemory Disorders/*drug therapy/etiology/pathology/physiopathologyNeural Cell Adhesion Molecules/*metabolismPhytotherapy/*methodsPolygala/*chemistryPositron-Emission Tomography/methodsRatsRats, WistarStress, Psychological/complications
Abstract
In Oriental medicine, roots of Polygala tenuifolia Willdenow have been known to be an important herb that exhibits sedative effects in insomnia, palpitation with anxiety, restlessness, and disorientation in humans. We previously reported that BT-11, extracted from those roots, improved scopolamine-induced amnesia in rats and inhibited acetylcholinesterase activities in vitro. Therefore, we proposed that BT-11 could remedy stress-induced memory deficits in rats. In this study, the stress-induced memory impairments in rats were significantly reversed almost to the control level by BT-11 treatment. To seek an active component of BT-11 that plays an important role in antipsychotic effects, we compared BT-11 with 3,4,5-trimethoxycinnamic acid (TMCA), which is a constituent of those root extracts. However, the effects of TMCA were less or were not consistent with those of BT-11 in some of tests. In particular, BT-11 reversed the stress-induced reduction of glucose utilization by [(18)fluorodeoxyglucose]FDG-PET and the levels of neural cell adhesion molecule (NCAM) in rat brains to the control levels, whereas TMCA did not. Therefore, BT-11 improved stress-induced memory impairments through increment of glucose utilization and total NCAM levels in rat brains. In conclusion, BT-11 may be strongly effective against stress-induced amnesia in rats, through the combined effects of TMCA and other active components of BT-11.
ISSN
1097-4547 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18712849

http://hdl.handle.net/10371/67808
DOI
https://doi.org/10.1002/jnr.21834
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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