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Preclinical efficacy of the c-Met inhibitor CE-355621 in a U87 MG mouse xenograft model evaluated by 18F-FDG small-animal PET

Cited 45 time in Web of Science Cited 46 time in Scopus
Authors
Tseng, Jeffrey R; Kang, Keon Wook; Dandekar, Mangal; Yaghoubi, Shahriar; Lee, Joseph H; Christensen, James G; Muir, Stephen; Gambhir, Sanjiv S
Issue Date
2007-12-14
Publisher
The Society of Nuclear Medicine Inc
Citation
J Nucl Med. 2008;49(1):129-134
Keywords
AnimalsAntibodies, Monoclonal/*pharmacologyAntineoplastic Agents/*pharmacologyCell Line, TumorDrug AntagonismFluorodeoxyglucose F18/*pharmacokineticsGlioblastomaHumansMiceMice, NudeNeoplasm TransplantationPositron-Emission Tomography/methodsProto-Oncogene Proteins c-met/*antagonists & inhibitorsRadiopharmaceuticals/*pharmacokineticsTransplantation, Heterologous
Abstract
The purpose of this study was to evaluate the efficacy of CE-355621, a novel antibody against c-Met, in a subcutaneous U87 MG xenograft mouse model using (18)F-FDG small-animal PET. METHODS: CE-355621 or control vehicle was administered intraperitoneally into nude mice (drug-treated group, n = 12; control group, n = 14) with U87 MG subcutaneous tumor xenografts. Drug efficacy was evaluated over 2 wk using (18)F-FDG small-animal PET and compared with tumor volume growth curves. RESULTS: The maximum %ID/g (percentage injected dose per gram of tissue) of (18)F-FDG accumulation in mice treated with CE-355621 remained essentially unchanged over 2 wk, whereas the %ID/g of the control tumors increased 66% compared with the baseline. Significant inhibition of (18)F-FDG accumulation was seen 3 d after drug treatment, which was earlier than the inhibition of tumor volume growth seen at 7 d after drug treatment. CONCLUSION: CE-355621 is an efficacious novel antineoplastic chemotherapeutic agent that inhibits (18)F-FDG accumulation earlier than tumor volume changes in a mouse xenograft model. These results support the use of (18)F-FDG PET to assess early tumor response for CE-355621.
ISSN
0161-5505 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18077531

http://jnm.snmjournals.org/cgi/reprint/49/1/129.pdf

http://hdl.handle.net/10371/67813
DOI
https://doi.org/10.2967/jnumed.106.038836
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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