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Preclinical efficacy of the c-Met inhibitor CE-355621 in a U87 MG mouse xenograft model evaluated by 18F-FDG small-animal PET
Cited 49 time in
Web of Science
Cited 50 time in Scopus
- Authors
- Issue Date
- 2007-12-14
- Publisher
- The Society of Nuclear Medicine Inc
- Citation
- J Nucl Med. 2008;49(1):129-134
- Keywords
- Animals ; Antibodies, Monoclonal/*pharmacology ; Antineoplastic Agents/*pharmacology ; Cell Line, Tumor ; Drug Antagonism ; Fluorodeoxyglucose F18/*pharmacokinetics ; Glioblastoma ; Humans ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Positron-Emission Tomography/methods ; Proto-Oncogene Proteins c-met/*antagonists & inhibitors ; Radiopharmaceuticals/*pharmacokinetics ; Transplantation, Heterologous
- Abstract
- The purpose of this study was to evaluate the efficacy of CE-355621, a novel antibody against c-Met, in a subcutaneous U87 MG xenograft mouse model using (18)F-FDG small-animal PET. METHODS: CE-355621 or control vehicle was administered intraperitoneally into nude mice (drug-treated group, n = 12; control group, n = 14) with U87 MG subcutaneous tumor xenografts. Drug efficacy was evaluated over 2 wk using (18)F-FDG small-animal PET and compared with tumor volume growth curves. RESULTS: The maximum %ID/g (percentage injected dose per gram of tissue) of (18)F-FDG accumulation in mice treated with CE-355621 remained essentially unchanged over 2 wk, whereas the %ID/g of the control tumors increased 66% compared with the baseline. Significant inhibition of (18)F-FDG accumulation was seen 3 d after drug treatment, which was earlier than the inhibition of tumor volume growth seen at 7 d after drug treatment. CONCLUSION: CE-355621 is an efficacious novel antineoplastic chemotherapeutic agent that inhibits (18)F-FDG accumulation earlier than tumor volume changes in a mouse xenograft model. These results support the use of (18)F-FDG PET to assess early tumor response for CE-355621.
- ISSN
- 0161-5505 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18077531
http://jnm.snmjournals.org/cgi/reprint/49/1/129.pdf
https://hdl.handle.net/10371/67813
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