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Nonaspirin nonsteroidal anti-inflammatory drugs and hemorrhagic stroke risk: the Acute Brain Bleeding Analysis study

Cited 18 time in Web of Science Cited 21 time in Scopus
Authors
Choi, Nam-Kyong; Park, Byung-Joo; Jeong, Sang-Wuk; Yu, Kyung-Ho; Yoon, Byung-Woo
Issue Date
2008-02-09
Publisher
American Heart Association
Citation
Stroke. 2008;39(3):845-859
Keywords
Acute DiseaseAdultAgedAged, 80 and overAnti-Inflammatory Agents, Non-Steroidal/*adverse effectsAsian Continental Ancestry GroupAspirinCase-Control StudiesCerebral Hemorrhage/*chemically induced/*complicationsHumansMiddle AgedOdds RatioRisk AssessmentStroke/*etiologySubarachnoid Hemorrhage/chemically induced/complications
Abstract
BACKGROUND AND PURPOSE: The relationship between nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and hemorrhagic stroke (HS) remains unclear. We examined the risk of HS associated with the use of NANSAIDs in Koreans. METHODS: We performed a nationwide, multicenter case-control study from 2002 to 2004. This study included 940 nontraumatic acute HS cases in patients aged 30 to 84 years, with an absence of a history of stroke or hemorrhage-prone brain lesions, alongside 940 community controls, matched to each case by age and sex. Pretrained interviewers obtained information on prescription drugs as well as over-the-counter drugs taken within 14 days before the onset of stroke. We adjusted potential confounders, including family histories of stroke, histories of hypertension, smoking, alcohol consumption, high salt intake, and laborious work hours. The adjusted ORs and their 95% CIs were calculated by conditional logistic regression. RESULTS: The proportion of NANSAIDs exposure within 14 days was 2.9% for HS patients and 2.0% for the controls. The adjusted odds ratios of stroke in NANSAIDs users compared with nonusers was 1.12 (95% CI, 0.77 to 1.65) for all HS, 1.03 (95% CI, 0.49 to 2.18) for subarachnoid hemorrhage, and 1.19 (95% CI, 0.76 to 1.87) for intracerebral hemorrhage. CONCLUSIONS: No increased risk of HS either subarachnoid hemorrhage or intracerebral hemorrhage was found among NANSAIDs users.
ISSN
1524-4628 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18258834

http://stroke.ahajournals.org/cgi/reprint/39/3/845.pdf

http://hdl.handle.net/10371/67829
DOI
https://doi.org/10.1161/STROKEAHA.107.497040
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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