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High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus

Cited 52 time in Web of Science Cited 56 time in Scopus
Authors
Choi, Sung Hee; Kwak, Soo Heon; Youn, Byung-Soo; Lim, Soo; Park, Young Joo; Lee, Hyewon; Lee, Namseok; Cho, Young Min; Lee, Hong Kyu; Kim, Young-Bum; Park, Kyong Soo; Jang, Hak C
Issue Date
2008-05-22
Publisher
Endocrine Society
Citation
J Clin Endocrinol Metab. 93(8):3142-3148
Keywords
Adiponectin/*bloodAdultDiabetes, Gestational/*bloodFemaleGlucose Intolerance/*bloodHumansLinear ModelsMetabolic Syndrome X/bloodPrealbumin/analysisPregnancyRetinol-Binding Proteins, Plasma/*analysis
Abstract
CONTEXT: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. OBJECTIVE: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT after GDM (GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). RESULTS: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. CONCLUSIONS: The severity of glucose intolerance in women with pGDM is associated with high RBP4 and low adiponectin concentrations.
ISSN
0021-972X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18492757

http://jcem.endojournals.org/cgi/reprint/93/8/3142.pdf

http://hdl.handle.net/10371/67928
DOI
https://doi.org/10.1210/jc.2007-1755
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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