Publications

Detailed Information

High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus

DC Field Value Language
dc.contributor.authorChoi, Sung Hee-
dc.contributor.authorKwak, Soo Heon-
dc.contributor.authorYoun, Byung-Soo-
dc.contributor.authorLim, Soo-
dc.contributor.authorPark, Young Joo-
dc.contributor.authorLee, Hyewon-
dc.contributor.authorLee, Namseok-
dc.contributor.authorCho, Young Min-
dc.contributor.authorLee, Hong Kyu-
dc.contributor.authorKim, Young-Bum-
dc.contributor.authorPark, Kyong Soo-
dc.contributor.authorJang, Hak C-
dc.date.accessioned2010-06-28T05:41:41Z-
dc.date.available2010-06-28T05:41:41Z-
dc.date.issued2008-05-22-
dc.identifier.citationJ Clin Endocrinol Metab. 93(8):3142-3148en
dc.identifier.issn0021-972X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18492757-
dc.identifier.urihttp://jcem.endojournals.org/cgi/reprint/93/8/3142.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/67928-
dc.description.abstractCONTEXT: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. OBJECTIVE: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT after GDM (GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). RESULTS: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. CONCLUSIONS: The severity of glucose intolerance in women with pGDM is associated with high RBP4 and low adiponectin concentrations.en
dc.language.isoenen
dc.publisherEndocrine Societyen
dc.subjectAdiponectin/*blooden
dc.subjectAdulten
dc.subjectDiabetes, Gestational/*blooden
dc.subjectFemaleen
dc.subjectGlucose Intolerance/*blooden
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMetabolic Syndrome X/blooden
dc.subjectPrealbumin/analysisen
dc.subjectPregnancyen
dc.subjectRetinol-Binding Proteins, Plasma/*analysisen
dc.titleHigh plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitusen
dc.typeArticleen
dc.contributor.AlternativeAuthor최성희-
dc.contributor.AlternativeAuthor곽수현-
dc.contributor.AlternativeAuthor윤병수-
dc.contributor.AlternativeAuthor임수-
dc.contributor.AlternativeAuthor박영주-
dc.contributor.AlternativeAuthor이혜원-
dc.contributor.AlternativeAuthor이남석-
dc.contributor.AlternativeAuthor조영민-
dc.contributor.AlternativeAuthor이홍규-
dc.contributor.AlternativeAuthor김영범-
dc.contributor.AlternativeAuthor박경수-
dc.identifier.doi10.1210/jc.2007-1755-
Appears in Collections:
Files in This Item:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share