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High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | Choi, Sung Hee | - |
dc.contributor.author | Kwak, Soo Heon | - |
dc.contributor.author | Youn, Byung-Soo | - |
dc.contributor.author | Lim, Soo | - |
dc.contributor.author | Park, Young Joo | - |
dc.contributor.author | Lee, Hyewon | - |
dc.contributor.author | Lee, Namseok | - |
dc.contributor.author | Cho, Young Min | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Kim, Young-Bum | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Jang, Hak C | - |
dc.date.accessioned | 2010-06-28T05:41:41Z | - |
dc.date.available | 2010-06-28T05:41:41Z | - |
dc.date.issued | 2008-05-22 | - |
dc.identifier.citation | J Clin Endocrinol Metab. 93(8):3142-3148 | en |
dc.identifier.issn | 0021-972X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18492757 | - |
dc.identifier.uri | http://jcem.endojournals.org/cgi/reprint/93/8/3142.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/67928 | - |
dc.description.abstract | CONTEXT: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. OBJECTIVE: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT after GDM (GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). RESULTS: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. CONCLUSIONS: The severity of glucose intolerance in women with pGDM is associated with high RBP4 and low adiponectin concentrations. | en |
dc.language.iso | en | en |
dc.publisher | Endocrine Society | en |
dc.subject | Adiponectin/*blood | en |
dc.subject | Adult | en |
dc.subject | Diabetes, Gestational/*blood | en |
dc.subject | Female | en |
dc.subject | Glucose Intolerance/*blood | en |
dc.subject | Humans | en |
dc.subject | Linear Models | en |
dc.subject | Metabolic Syndrome X/blood | en |
dc.subject | Prealbumin/analysis | en |
dc.subject | Pregnancy | en |
dc.subject | Retinol-Binding Proteins, Plasma/*analysis | en |
dc.title | High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 최성희 | - |
dc.contributor.AlternativeAuthor | 곽수현 | - |
dc.contributor.AlternativeAuthor | 윤병수 | - |
dc.contributor.AlternativeAuthor | 임수 | - |
dc.contributor.AlternativeAuthor | 박영주 | - |
dc.contributor.AlternativeAuthor | 이혜원 | - |
dc.contributor.AlternativeAuthor | 이남석 | - |
dc.contributor.AlternativeAuthor | 조영민 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 김영범 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.identifier.doi | 10.1210/jc.2007-1755 | - |
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