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The G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1) and its serum and peritoneal fluid levels in Korean women with endometriosis

Cited 9 time in Web of Science Cited 8 time in Scopus
Authors
Kim, Ja Yeon; Kim, Hoon; Suh, Chang Suk; Kim, Seok Hyun; Choi, Young Min; Kim, Jung Gu
Issue Date
2007-12-11
Publisher
Elsevier
Citation
Eur J Obstet Gynecol Reprod Biol. 2008;139(1):106-110
Keywords
AdultAscitic Fluid/chemistryCase-Control StudiesChemokine CCL2/blood/*geneticsEndometriosis/*geneticsFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansKoreaPolymorphism, Single Nucleotide/*geneticsUterine Diseases/*genetics
Abstract
OBJECTIVES: To investigate the associations between endometriosis and the G(-2518)A polymorphism of monocyte chemotactic protein-1 (MCP-1), and serum and peritoneal fluid MCP-1 levels in Korean women. STUDY DESIGN: The G(-2518)A polymorphism of MCP-1 was analyzed by restriction fragment length polymorphism in 105 women with and in 101 women without endometriosis. Serum and peritoneal fluid MCP-1 levels were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: The genotype frequencies of the MCP-1 G (-2518)A polymorphism were GG 36.9%, AG 52.9%, and AA 10.2%. MCP-1 genotype frequencies and serum and peritoneal fluid MCP-1 levels were similar in those with or without endometriosis and were not dependent on disease stage. A significant correlation was found between serum and peritoneal fluid levels of MCP-1. However, no differences were found between MCP-1 genotypes in terms of serum and peritoneal fluid MCP-1 levels. CONCLUSIONS: Serum and peritoneal fluid MCP-1 levels and the G (-2518)A MCP-1 polymorphism were found not to be associated with endometriosis in Korean women.
ISSN
0301-2115 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18069114

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T69-4RB5GPB-2-4&_cdi=5025&_user=168665&_orig=search&_coverDate=07%2F31%2F2008&_sk=998609998&view=c&wchp=dGLzVzz-zSkzS&md5=5d2ebec02268a0c7428c8f3b2ec8e84d&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68052
DOI
https://doi.org/10.1016/j.ejogrb.2007.10.009
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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