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Validation of a nomogram for predicting outcome of vulvar cancer patients, primarily treated by surgery, in Korean population: multicenter retrospective study through Korean Gynecologic Oncology Group (KGOG-1010)

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Authors
Kim, Mi-Kyung; Kim, Jae Weon; Lee, Jong-Min; Lee, Nak-Woo; Cha, Moon-Seok; Kim, Byoung-Gie; Lee, Ki Heon; Kim, Young-Tae; Kim, Jae-Hoon; Song, Eun-Seop; Kim, Moon-Hong; Ryu, Sang-Young; Kim, Won Gyu; Kim, Young-Tak; Kim, Kyung-Tai; Kang, Soon-Beom
Issue Date
2009-05-28
Publisher
Korean Society of Gynecologic Oncology and Colposcopy
Citation
J Gynecol Oncol. 2008; 19(3): 191-194
Keywords
Vulvar cancerNomogramExternal validationPrediction
Abstract
OBJECTIVE: Regarding vulvar cancer, a nomogram has been suggested for the prediction of relapse-free survival (RFS). While the nomogram has been developed and validated in a Western study, there was no validation in Korean population. Thus, we have undertaken the study to assess the applicability of nomogram for predicting RFS in Korean patients with vulvar cancer. METHODS: A total of 204 cases newly diagnosed as vulvar cancer between 1982 and 2006 were identified. Among them 70 cases were not eligible due to inappropriate cell type (40 cases) and radiation as primary therapy (30 cases). Forty-four cases were not evaluable due to inadequate data and persistent disease. Finally a total of 90 patients primarily treated by surgery were included for analysis. Variables including age and the characteristics of primary tumor, nodal status, and surgical margin were collected for predicting RFS based on nomogram, which was compared with actual RFS. A calibration plot was drawn showing the actual versus predicted probability for 6 groups of patients segregated according to their predicted probabilities. In addition, discrimination of the nomogram was quantified with the concordance index. RESULTS: Patients' mean age was 58 years and mean follow-up period was 47.9 months. Observed 2y- and 5y-RFS rates were 81% and 68%, respectively, corresponding to 79% and 72% in the original cohort. The trend line in calibration plot showed comparable concordance with an ideal line, having a slope of 1.04 for 2y-RFS (R(2)=.35) and 0.98 for 5y-RFS (R(2)=.80), respectively. The concordance index was 0.79 in the KGOG data set, which was improved to 0.82 with the data set limited to squamous cell carcinoma. CONCLUSION: The nomogram provides the predictive capacity for relapse-free survival in Korean patients with vulvar cancer.
ISSN
2005-0380 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19471576

http://synapse.koreamed.org/Synapse/Data/PDFData/1114JGO/jgo-19-191.pdf

http://hdl.handle.net/10371/68059
DOI
https://doi.org/10.3802/jgo.2008.19.3.191
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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