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Association of leptin receptor polymorphisms Lys109Arg and Gln223Arg with serum leptin profile and bone mineral density in Korean women

Cited 18 time in Web of Science Cited 21 time in Scopus
Authors
Kim, Sun Mie; Kim, Seok Hyun; Lee, Jung Ryeol; Jee, Byung Chul; Ku, Seung-Yup; Suh, Chang Suk; Choi, Young Min; Kim, Jung Gu; Moon, Shin Yong
Issue Date
2008-02-05
Publisher
Elsevier
Citation
Am J Obstet Gynecol. 2008;198(4):421.e1-421.e8
Keywords
AdultAllelesBody Weights and MeasuresBone Density/*geneticsCross-Sectional StudiesEstradiol/*bloodFemaleGenotypeGlycine/geneticsHumansKoreaLeptin/*blood/geneticsLysine/geneticsMiddle AgedPolymorphism, GeneticPostmenopausePremenopauseReceptors, Leptin/*genetics
Abstract
OBJECTIVE: The objective of the study was to examine the relationship of the LEPR Lys109Arg and Gln223Arg polymorphisms and the serum leptin profile and bone mineral density (BMD). STUDY DESIGN: Cross-sectional study on a cohort of 145 premenopausal and 118 postmenopausal Korean women. The BMDs and serum levels of leptin, the soluble leptin receptor (sLR), and estradiol were measured, and the LEPR gene was genotyped. RESULTS: The distributions of the LEPR Lys109Arg and Gln223Arg polymorphisms in all study subjects are as follows: Lys/Lys, 2.7%; Lys/Arg, 27.0%; Arg/Arg, 70.3%; Gln/Gln, 2.7%, Gln/Arg, 19.8%, and Arg/Arg, 77.5%, respectively. Premenopausal subjects carrying the Lys109 allele had a higher total hip BMD (P = .044) and showed a nonsignificant trend toward a higher femoral neck and lumbar BMD than the subjects without this allele. CONCLUSION: Our study suggests the LEPR Lys109Arg polymorphism is one of the genetic determinants of the peak bone mass in Korean women.
ISSN
1097-6868 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18241826

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6W9P-4RR8341-4-5&_cdi=6688&_user=168665&_orig=search&_coverDate=04%2F30%2F2008&_sk=998019995&view=c&wchp=dGLzVlz-zSkWz&md5=38eaa7653d1b94119c71dc0d6733317f&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68063
DOI
https://doi.org/10.1016/j.ajog.2007.10.799
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College of Medicine/School of Medicine (의과대학/대학원)Obstetrics & Gynecology (산부인과전공)Journal Papers (저널논문_산부인과학전공)
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