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Does the diagnostic accuracy of the 13C-urea breath test vary with age even after the application of urea hydrolysis rate?

Cited 11 time in Web of Science Cited 16 time in Scopus
Authors
Yang, Hye Ran; Ko, Jae Sung; Seo, Jeong Kee
Issue Date
2008-07-31
Publisher
Wiley-Blackwell
Citation
Helicobacter. 2008;13(4):239-244
Keywords
AdolescentAge FactorsBacterial Proteins/metabolismBreath Tests/*methodsCalibrationCarbon Isotopes/metabolismChildChild, PreschoolEndoscopy, GastrointestinalFalse Positive ReactionsFemaleHelicobacter Infections/*diagnosis/metabolism/*microbiology/pathologyHelicobacter pylori/isolation & purification/*metabolismHumansHydrolysisInfantMaleUrea/*analysis/metabolismUrease/metabolism
Abstract
BACKGROUND: Endogenous CO(2) production may be a possible explanation for higher false-positive results reported for (13)C-urea breath test (UBT) in children below 6 years. In this study, we evaluated whether age affects the diagnostic accuracy of the (13)C-UBT even after the application of urea hydrolysis rate (UHR) in children. METHODS: A total of 612 (13)C-UBTs and endoscopic biopsies were performed on children divided into two groups; children under 6 years (n = 126) and children aged 6-18 years (n = 486). For (13)C-UBT, 75 mg (13)C-urea was ingested, and breath sample was collected 30 minutes later. Delta over baseline (DOB) was determined, and UHR was calculated to normalize the DOB values for endogenous CO(2) production. RESULTS: There was significant difference between the DOB values of children under 6 years and those of children over 6 years in H. pylori-positive (p = .029) and -negative groups (p = .002). On applying the UHR, no significant difference was observed between the UHR values of children under 6 years and those of children over 6 years in H. pylori-positive (p = .877) and -negative groups (p = .427). In 12.6% children under 6 years, false-positive results were observed on applying the DOB, and in 9.0% on applying the UHR (p = .125). CONCLUSIONS: The (13)C-UBT is a noninvasive method exhibiting high diagnostic accuracy with both UHR as well as DOB. However, high false-positive results for (13)C-UBT were noted in children below 6 years on applying both UHR as well as DOB. Thus, this may not only be due to the effects of endogenous CO(2) production but also due to other factors.
ISSN
1523-5378 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18665931

http://hdl.handle.net/10371/68152
DOI
https://doi.org/10.1111/j.1523-5378.2008.00608.x
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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