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Ghrelin enhances the proliferating effect of thyroid stimulating hormone in FRTL-5 thyroid cells

DC Field Value Language
dc.contributor.authorPark, Young Joo-
dc.contributor.authorLee, You Jin-
dc.contributor.authorKim, Soon Hee-
dc.contributor.authorJoung, Duck Soon-
dc.contributor.authorKim, Byung Joo-
dc.contributor.authorSo, Insuk-
dc.contributor.authorPark, Do Joon-
dc.contributor.authorCho, Bo Youn-
dc.date.accessioned2010-07-01T23:15:09Z-
dc.date.available2010-07-01T23:15:09Z-
dc.date.issued2008-03-04-
dc.identifier.citationMol Cell Endocrinol. 285(1-2), 19-25en
dc.identifier.issn0303-7207 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18313206-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T3G-4RM7N3C-2-3&_cdi=4946&_user=168665&_orig=search&_coverDate=03%2F26%2F2008&_sk=997149998&view=c&wchp=dGLzVtz-zSkWA&md5=7d4911efb4c606529ef9309221317897&ie=/sdarticle.pdf-
dc.identifier.urihttps://hdl.handle.net/10371/68175-
dc.description.abstractGhrelin regulates cell proliferation through the growth hormone secretagogue receptor (GHS-R). We confirmed the expression of GHS-R in FRTL-5 thyroid cells and investigated the effects of ghrelin in thyrocytes using FRTL-5 cells. Ghrelin increased intracellular calcium levels but not intracellular cyclic AMP levels. Ghrelin activated Erk within 2min, then activated Akt and STAT3. Erk phosphorylation was inhibited by the calcium inhibitor cyclopiazonic acid (CPA). Ghrelin alone did not stimulate FRTL-5 cell proliferation but enhanced the effects of thyroid stimulating hormone (TSH). Pretreatment with TSH potentiates the growth effects of ghrelin in thyroid cells, and p66Shc, a growth factor receptor adaptor protein, might mediate these synergistic effects. Ghrelin phosphorylated TSH-induced p66Shc, which was inhibited by CPA. Ghrelin did not affect the proliferation of ARO cells, which showed no increased expression of p66Shc after TSH treatment. Thus, ghrelin-induced intracellular calcium signaling enhanced the TSH-induced proliferation of thyrocytes, possibly mediated by the p66Shc pathway.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdaptor Proteins, Signal Transducing/genetics/metabolismen
dc.subjectAnimalsen
dc.subjectCalcium/metabolismen
dc.subjectCell Lineen
dc.subjectCyclic AMP/metabolismen
dc.subjectEnzyme Activationen
dc.subjectExtracellular Signal-Regulated MAP Kinases/metabolismen
dc.subjectGhrelin/genetics/*metabolismen
dc.subjectHumansen
dc.subjectProto-Oncogene Proteins c-akt/metabolismen
dc.subjectRatsen
dc.subjectReceptors, Ghrelin/genetics/*metabolismen
dc.subjectSTAT3 Transcription Factor/metabolismen
dc.subjectShc Signaling Adaptor Proteinsen
dc.subjectSignal Transduction/physiologyen
dc.subjectThyroid Gland/*cytology/metabolismen
dc.subjectThyrotropin/*metabolismen
dc.subjectCell Proliferation-
dc.titleGhrelin enhances the proliferating effect of thyroid stimulating hormone in FRTL-5 thyroid cellsen
dc.typeArticleen
dc.contributor.AlternativeAuthor박영주-
dc.contributor.AlternativeAuthor이유진-
dc.contributor.AlternativeAuthor김순희-
dc.contributor.AlternativeAuthor정덕순-
dc.contributor.AlternativeAuthor김병주-
dc.contributor.AlternativeAuthor소인석-
dc.contributor.AlternativeAuthor박도준-
dc.contributor.AlternativeAuthor조보연-
dc.identifier.doi10.1016/j.mce.2008.01.003-
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