S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
- Hwang, Jin-Hyeok; Lee, Sang Hyub; Lee, Kwang Hyuck; Lee, Keung Youp; Kim, Haeryoung; Ryu, Ji Kon; Yoon, Yong Bum; Kim, Yong-Tae
- Issue Date
- Cancer Lett. 273 (2009) 266-272
- Adult; Aged; Aged, 80 and over; Cathepsin B/*metabolism; Cell Line, Tumor; Female; *Gene Expression Regulation, Neoplastic; Hedgehog Proteins/*metabolism; Humans; Male; Middle Aged; Neoplasm Invasiveness; Pancreatic Neoplasms/*metabolism; RNA, Messenger/metabolism; Signal Transduction
- This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P<0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P=0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness.
- 1872-7980 (Electronic)
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