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Cathepsin B is a target of Hedgehog signaling in pancreatic cancer

Cited 19 time in Web of Science Cited 22 time in Scopus
Authors
Hwang, Jin-Hyeok; Lee, Sang Hyub; Lee, Kwang Hyuck; Lee, Keung Youp; Kim, Haeryoung; Ryu, Ji Kon; Yoon, Yong Bum; Kim, Yong-Tae
Issue Date
2009
Publisher
Elsevier
Citation
Cancer Lett. 273 (2009) 266-272
Keywords
AdultAgedAged, 80 and overCathepsin B/*metabolismCell Line, TumorFemale*Gene Expression Regulation, NeoplasticHedgehog Proteins/*metabolismHumansMaleMiddle AgedNeoplasm InvasivenessPancreatic Neoplasms/*metabolismRNA, Messenger/metabolismSignal Transduction
Abstract
This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P<0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P=0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness.
ISSN
1872-7980 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19004543

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T54-4TWSWTR-1-7&_cdi=4992&_user=168665&_orig=search&_coverDate=01%2F18%2F2009&_sk=997269997&view=c&wchp=dGLzVlz-zSkzS&md5=59693b177fcb93a184c89a2c04b3a0f3&ie=/sdarticle.pdf

http://hdl.handle.net/10371/68198
DOI
https://doi.org/10.1016/j.canlet.2008.08.028
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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