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Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
Cited 20 time in
Web of Science
Cited 23 time in Scopus
- Authors
- Issue Date
- 2009
- Publisher
- Elsevier
- Citation
- Cancer Lett. 273 (2009) 266-272
- Keywords
- Adult ; Aged ; Aged, 80 and over ; Cathepsin B/*metabolism ; Cell Line, Tumor ; Female ; Hedgehog Proteins/*metabolism ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Pancreatic Neoplasms/*metabolism ; RNA, Messenger/metabolism ; Signal Transduction ; Gene Expression Regulation, Neoplastic
- Abstract
- This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P<0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P=0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness.
- ISSN
- 1872-7980 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19004543
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T54-4TWSWTR-1-7&_cdi=4992&_user=168665&_orig=search&_coverDate=01%2F18%2F2009&_sk=997269997&view=c&wchp=dGLzVlz-zSkzS&md5=59693b177fcb93a184c89a2c04b3a0f3&ie=/sdarticle.pdf
https://hdl.handle.net/10371/68198
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