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Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Jin-Hyeok | - |
dc.contributor.author | Lee, Sang Hyub | - |
dc.contributor.author | Lee, Kwang Hyuck | - |
dc.contributor.author | Lee, Keung Youp | - |
dc.contributor.author | Kim, Haeryoung | - |
dc.contributor.author | Ryu, Ji Kon | - |
dc.contributor.author | Yoon, Yong Bum | - |
dc.contributor.author | Kim, Yong-Tae | - |
dc.date.accessioned | 2010-07-04T23:21:35Z | - |
dc.date.available | 2010-07-04T23:21:35Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Cancer Lett. 273 (2009) 266-272 | en |
dc.identifier.issn | 1872-7980 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19004543 | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6T54-4TWSWTR-1-7&_cdi=4992&_user=168665&_orig=search&_coverDate=01%2F18%2F2009&_sk=997269997&view=c&wchp=dGLzVlz-zSkzS&md5=59693b177fcb93a184c89a2c04b3a0f3&ie=/sdarticle.pdf | - |
dc.identifier.uri | https://hdl.handle.net/10371/68198 | - |
dc.description.abstract | This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P<0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P=0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness. | en |
dc.description.sponsorship | This study was supported in part by the Seoul National
University College of Medicine Research Fund 800- 20070072. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Cathepsin B/*metabolism | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Female | en |
dc.subject | Hedgehog Proteins/*metabolism | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neoplasm Invasiveness | en |
dc.subject | Pancreatic Neoplasms/*metabolism | en |
dc.subject | RNA, Messenger/metabolism | en |
dc.subject | Signal Transduction | en |
dc.subject | Gene Expression Regulation, Neoplastic | - |
dc.title | Cathepsin B is a target of Hedgehog signaling in pancreatic cancer | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 황진혁 | - |
dc.contributor.AlternativeAuthor | 이상협 | - |
dc.contributor.AlternativeAuthor | 이광혁 | - |
dc.contributor.AlternativeAuthor | 류지곤 | - |
dc.contributor.AlternativeAuthor | 김해령 | - |
dc.contributor.AlternativeAuthor | 윤용범 | - |
dc.contributor.AlternativeAuthor | 김용태 | - |
dc.contributor.AlternativeAuthor | 이경엽 | - |
dc.identifier.doi | 10.1016/j.canlet.2008.08.028 | - |
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