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College of Medicine/School of Medicine (의과대학/대학원)
Ophthalmology (안과학전공)
Journal Papers (저널논문_안과학전공)
N-myc amplification was rarely detected by fluorescence in situ hybridization in retinoblastoma
- Issue Date
- 2008-06-10
- Publisher
- Elsevier
- Citation
- Hum Pathol. 2008;39(8):1172-1175
- Keywords
- Adolescent ; Adult ; Child ; Eye Neoplasms/*genetics ; Female ; Genes, myc/*genetics ; Genetic Markers ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Retinoblastoma/*genetics ; Gene Amplification
- Abstract
- In retinoblastoma, genetic alteration of N-myc amplification different from the alteration of the RB1 gene on chromosome 13q14 has been described. This study is to determine the frequency of N-myc amplification by fluorescence in situ hybridization method in retinoblastoma. This study was prospectively derived from 26 patients who were diagnosed as having unilateral retinoblastoma (highly progressive large retinoblastoma, group 5 in Reese-Ellsworth classification) and underwent enucleation. We performed locus-specific fluorescence in situ hybridization probes for N-myc gene. Our results demonstrated that in only one of 26 patients was N-myc amplification found in retinoblastoma tissue. N-myc amplification has been regarded as one characteristic of retinoblastoma cell line and an adverse prognostic factor. However, our study indicates that N-myc amplification is not frequently found in retinoblastoma.
- ISSN
- 1532-8392 (Electronic)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18538370
http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WGD-4SNXT39-1-3&_cdi=6820&_user=168665&_orig=search&_coverDate=08%2F31%2F2008&_sk=999609991&view=c&wchp=dGLbVtz-zSkWA&md5=0a8a6132ca648aa53b24e17dfce7798b&ie=/sdarticle.pdf
https://hdl.handle.net/10371/68205
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